I'm Pullin' My Hair Out! (Feline Alopecia)
All cats shed whether it's a lot or a little. It's a natural cycle for a cat as the seasons come and numerous factors affect the coat quality. What is not normal are bald or missing patches of fur. This is called (no matter the cause) alopecia. If your companion seems to be missing quite a lot of fur in large clumps and patches resulting in baldness, as your cat’s caregiver it is now your mission to find out what is causing it (1).
Over-grooming and skin allergies tend to often be umbrella terms for a slew of illnesses and disease affecting the skin (1,2). In general grooming for a cat is an activity that takes up a lot of their time (often 30-50% of their time) (3) and is a basic way to calm themselves (1). Over-grooming involves obsessive licking of the fur resulting in inflammation, open wounds and/or hair loss. This act is often triggered by stress or anxiety (1) as well as primary illness or disease.
Sources of stress can be far and many and often coincide with similar stressors that bring on inappropriate urination habits. Stress could be something big and traumatic or seemingly small to us humans. Stressors can include but is not limited to:
Changes in litter or litter box (scent, texture, location)
New perfume or cologne you or your family wears
New furniture or move of furniture
Change in work or school schedule
New cat, baby, other pet, girl/boyfriend
Wandering animals outside
Another pet or child beating up or ganging up on them
A move to a new house
Other causes of feline alopecia often result from illness and/or disease.
Food Allergies are typically abnormal immune responses to an antigen found in food (4) and in direct relation to hair loss is often characterized by head and facial hair loss (1) but can also be seen on the belly, groin, legs and paws (4) however other signs include fluid-filled lumps, skin lesions and poor coat. A food allergy often does not appear out of the blue, it is typically developing over time (2) and is not related to the seasons (4).
To determine food allergies a novel diet must be fed for 8-10 weeks (4) and then challenged to determine and eliminate the offending allergen in your companion’s (2) Conventional Options: Prescription Diets Commercial dry or canned food *Note these diets often are what are actually causing the allergy in the first place
Natural Options: Species appropriate raw diet
Contact dermatitis occurs when a cat typically under the age of two is exposed to an external irritant. This substance can cause an allergic reaction (sensitivity or allergy) or an irritation (due to a harsh chemical or irritant in the cats’ environment.) Contact Dermatitis can occur from (but is not limited too):
Flea products (collars, sprays, dips, topicals)
Fertilizers and other garden products
Household products (soaps, cleaning products, solvents etc.)
The most common conventional treatments include:
Bathing the animal
Eliminating the allergen
Natural Eliminate chemical
Flea and tick products
Bath with natural shampoos and soak like oatmeal and baking soda Wipe the fur with a cloth to remove allergens Eliminate plastic food and water bowls
Natural antihistamines like pollinosan tablets
Invest in an air purifier
Boost the immune system with Vitamin C Herbals
Allergies can also come from triggers found in your companion’s environment including dust and pollen but it can be to anything that causes the immune system to cause a reaction such as inflammation and itching. This can include fragrances such as perfumes or colognes human use or in their litter as well as dust from litter.
Keep in mind that immune system malfunction can be a genetic trait!
While there are not true cures for allergies, treatment often includes:
Eliminating exposure to the allergen
Quercetin is a great natural antihistamine and anti-inflammatory (9).
FLEAS (1) Many cats are allergic to the saliva of fleas due to proteins and antigens found in the saliva. This causes itchiness and can lead to secondary skin infections. Cats that have this allergy do not have to have a flea infestation, it could come from just one flea bite. A good indicator that fleas are the offender is over-grooming around the base of the tail, neck and head.
To formally diagnose a flea allergy, a skin test and/or IgE blood test can be performed. Should your companion have a flea allergy, your veterinarian may prescribe a corticosteroid to provide relief from itching and prevent an allergic reaction from occurring (10)
Check our out Ultimate Guide to Fleas for Cats for detailed information about fleas and their treatment. MITES OR MANGE (1) There are several types of fairly contagious manges that cats can acquire including various species of scabies, ear mites and cheyletiellosis (or walking dandruff). This is often characterized by dandruff, thickening of the skin, crustiness and sores. If severe enough and untreated our feline friends can die from mange. After a skin scraping is performed by your veterinarian, if your companion is diagnosed with mites/mange you veterinarian may suggest medicated shampoo or a dip to remove the pest (11,12, 13). Natural options include: Apple Cider Vinegar bath Garlic Power (2 tablespoons) (14), Goldenseal Powder (two tablespoons) (15) and olive oil (¼ cup) paste
Fresh, raw papaya (topically) (16)
Oxycat from Two Crazy Cat Ladies
RINGWORM (1) Ringworm is actually a fungus not a worm and does not always present as a ring like often seen in humans.
Signs of ringworm include over grooming of the face, feet and ears. The skin can also turn gray and flakey. In severe cases the animal may look like it has been badly sunburnt. With some ringworm species, a black light can detect its presence however this is not a fool proof method. A skin scraping and fungal culture is the best way to diagnose ringworm, While it is a self-limiting fungus, it can take 3-5 month to resolve. Treatment involving medicated creams, ointments or shampoos as well as oral anti-fungal drugs are typically part of resolving ringworm (17). Natural Options Shaving (this prevents the spread of spores) Regular bathing
Fresh, raw papaya (topically) (18)
Aloe Vera gel (topically) (19)
Turmeric paste (oral or topical) (20)
Hyperthyroidism is a common disorder in cats where the thyroid is over working. In about a third of those cats have hair loss. In addition the coat looks poorly kept and oily. This often is caused by chemicals in the diet or the environment around them. It is also characterized by increased urination and drinking, increased weight loss despite increased appetite (21).
If you suspect your feline friend has a hyperthyroid a blood test, urinalysis and biochemistry often will be performed to diagnose this condition. Should they be diagnosed with a hyper thyroid medication is the most common prescription to maintain the disease. Surgery and/or radioactive iodine may also be recommended.
Natural Diet- Raw species appropriate diet, avoiding soy and fish (22)
Avoid sources of BPA including most plastics, canned foods (canned food linings contain BPA) (23)
Foods or natural supplements rich in carnitine (125 to 250 mg twice a day) (24) (25).
Herbs such as Bugleweed and Lemon Balm (26).
Use only natural chemical free flea, tick, dewormers etc. (27, 28, 29)
Catalyst from The Two Crazy Cat Ladies *Note there is not as much success with natural treatments but the above natural suggestions can help and in most cases PREVENT the development of hyperthyroidism.
Although not commonly seen in cats (1) and often primarily in older cats, Cushing’s disease is a result of hyper production of steroids from the adrenal gland (1). This disease is characterized by increased food, water intake and urination, enlarged liver and other similar symptoms to other illnesses like diabetes which can occur concurrently alongside regular urinary tract infections. You may see non uniform hair loss due to this condition (1). For this reason it is important to properly diagnose this condition with blood tests, urinalysis as well as ultrasound or x-ray.
If your feline friend is diagnosed with Cushing’s it can be managed with medication and/or surgery especially if the cause is an adrenal tumor (30)
Diet- Raw species appropriate diet, avoiding carbohydrates (fruits, veggies and grains is essential) Reduce and eliminate toxins used on, in and around your companion Reduce and eliminate stress
Sebaceous adenitis is characterized by patchy hair loss, easy removed hair from pulling, red patchy and itchy skin caused by an inflammation structure infiltrating the glands in the skin. This condition is diagnosed with a skin biopsy. Treatment includes pharmaceutical immunosuppressive drugs such as prednisolone.
Alopecia areata (AA) and pseudopelade While a rare disease, AA is the opposite of Sebaceous adenitis in that the skin is not inflamed or itchy. This disease is caused by white blood cells or lymphocytes infiltrating the bulbus and space between the skin ducts and the follicle. In order to diagnose AA examination of the hair, skin and tissues under a microscope is required. Often this disease can return a more dormant state primarily because immunosuppressive drugs are typically not effective (34). Natural options Species appropriate raw diet Full extract cannabis oil Reduce inflammation with Krill Oil Fish Oil Green lipped mussels Turmeric paste Catalyst from The Two Crazy Cat Ladies Oxycat from The Two Crazy Cat Ladies
Mural lymphocytic folliculitis
Mural lymphocytic folliculitis presents as mild hair loss to severe including peeling of the skin, skin redness and varying amount of itchiness. This disease can be also mistaken for “initial epitheliotropic lymphoma, drug reaction, sebaceous adenitis, dermatophytosis, demodicosis, pseudopelade, FIV infection and even food allergy” (31). Treatment often includes steroids and/or retinoids with prognosis depending on the severity of the disease.
Natural options Species appropriate raw diet Full extract cannabis oil Reduce inflammation with Krill Oil Fish Oil Green lipped mussels Turmeric paste White Vinegar Aloe Vera Manuka honey (32) Thyme Paste (33) Apple Cider Vinegar (IF THERE ARE NO OPEN WOUNDS) Baking soda soak/paste (see our article on fleas) Herbs such as Echinacea Catalyst from The Two Crazy Cat Ladies
Oxycat from The Two Crazy Cat Ladies
Another rare but possible cause for hair loss typically seen around the tummy and legs is often caused by cancer associated with the pancreas or bile duct. Itchy skin, over-grooming and licking also occur. This disease is also characterized by loose stool, vomiting, loss of appetite and lethargy. Unfortunately diagnosis is hard blood panels and radiographs or ultrasounds rarely catch the tumor and thus prognosis is poor. Even with surgery there can be a recurrence of the tumor (35, 36, 37). Natural options Species appropriate raw diet Full extract cannabis oil Reduce inflammation with Krill Oil Fish Oil Green lipped mussels Turmeric paste Catalyst from The Two Crazy Cat Ladies
Oxycat from The Two Crazy Cat Ladies
If your feline friend is suffering from pain, to help calm or make themselves feel better they may groom the area, the more of a pain the more they are likely to continue grooming to the point of over grooming. Some sources of pain can include
Impacted or infected anal glands can cause back end hairloss. Typical anal gland secretions are secreted during defecation but for some felines this may not happen. Natural Options Raw species appropriate diet including whole prey (fur and feathers is a natural fiber source) (38. 39, 40) Digestive Enzymes (40) Probiotic (41) Homeopathy such as Silica 30C Hepar sulph 30C (42) Warm compress Fish Oil (43)
Catalyst from The Two Crazy Cat Ladies
Urinary Tract Infection
Over-grooming will be seen around the belly Species appropriate raw diet
D-mannose (46, 47)
Colloidal Silver (48)
Over grooming due to arthritis will be see around the joints (1) Turmeric paste (52, 53
Green lipped mussels (54, 55)
Krill or Fish Oil (7) Gelatin from Bone Broth (56) Acupuncture (57, 58) Full Extract Cannabis Oil (59, 60, 61)
Abscess (1) Warm compress Salt water compress or soak (62)
Poor diet (1) Balanced and varied Raw species appropriate diet rich in Omega 3 fatty acids and skin/coat promoting ingredients. (63, 64, 65)
HAIR DAMAGE Any disease of trauma such as burns or radiation can affect the hair follicle such as medical injections and topical medications (30). This can also include fungus (ringworm for example) or parasites and poison like mercury or iodine that causes the skin to inflame.
Nutritional deficiencies and problems caused by poor diet heavily affect the skin and coat. This can create thinning, brittle hair and shedding cause hair loss and bald spots (67).
BEHAVIOR Obsessive Compulsive Disorder is typically brought on by behaviors responding to environmental conflicts that develop into repetitive events that eventually turn into behaviors that are not triggered by an identifiable stimuli (68). At times these behaviors turn into habits. OCD is often diagnosed when other diagnoses are eliminated and treatment often involves discovering the stressor and may involve the use of psychotropic drugs or drugs that alter the mental state of your feline companion. These can include:
Anti anxiety drugs such as amitriptyline or diazepam
Opiate-receptor blockers such as naltrexone, nalmefene and diprenorphine
Dopamine antagonists such as haloperidol
Serotonin reuptake Inhibitors such as fluoxetine, clomipramine, imipramine.
Natural Options Full Extract Cannabis Oil (69) Identify and reduce stressors (70) Bach Rescue Remedy (71) Herbs such as Catnip (72) Silver Vine (73) Valerian Root (73) Cat Calm from The Two Crazy Cat Ladies
GENETICS Finally congenital and genetic causes which can be characterized by local and random hair loss can occur. (1,66) This also includes breed predisposition in Siamese, Burmese, Himalayan and Abyssinian cats (74). As one can see, there are many causes for hair loss. In the long run on a basic level pulling fur is not entirely life threatening but cat owners should be aware that aside from primarily conditions, sores, open wounds and skin problems can develop that can become more serious as well. This may also open your companion up to skin infections, sunburns and other issues resulting for the lack of protection fur typically provides. It's important to seek help in determining the exact cause of feline alopecia in order to best help your companion.
1. Plotnick, Arnold. “Hair Loss in Cats: Manhattan Cat Specialists: Articles.” Manhattan Cat Specialists, 20 Sept. 2019, www.manhattancats.com/blog/2019/september/hair-loss-in-cats/.
2. “Feline Skin Diseases.” Cornell University College of Veterinary Medicine, 3 May 2019, www.vet.cornell.edu/departments-centers-and-institutes/cornell-feline-health-center/health-information/feline-health-topics/feline-skin-diseases.
3. DVM, Mary Fuller. “Why Does My Cat... Pull Her Hair Out?” Vetstreet, 6 May 2015, www.vetstreet.com/our-pet-experts/why-does-my-cat-pull-her-hair-out.
4. Barnette, Catherine. â€œFood Allergies in Cats.â€Â vca_corporate, 2018, vcahospitals.com/know-your-pet/food-allergies-in-cats.
5. Natural Health Bible for Dogs & Cats: Your A-Z Guide to over 200 Conditions, Herbs, Vitamins, and Supplements. Â Natural Health Bible for Dogs & Cats: Your A-Z Guide to over 200 Conditions, Herbs, Vitamins, and Supplements, by Shawn Messonnier, Three Rivers Press, 2001, pp. 177 and 193.
6. Calder, Philip C.; Kremmyda, Lefkothea-Stella; Vlachava, Maria; Noakes, Paul S.; Miles, Elizabeth A. (2010). "Is there a role for fatty acids in early life programming of the immune system?". Proceedings of the Nutrition Society. 69(3): 373–80. doi:10.1017/S0029665110001552. PMID 20462467
7. Calder, PC. “n-3 Polyunsaturated Fatty Acids, Inflammation, and Inflammatory Diseases.”PubMed.gov, Am J Clin Nutr., June 2006, www.ncbi.nlm.nih.gov/pubmed/16841861.
8. Daniells, Stephen. â€œStudies Support Green-Lipped Mussel's Anti-Inflammatory Properties.â€Â Nutraingredients.com, William Reed Business Media Ltd., 28 Aug. 2007, www.nutraingredients.com/Article/2007/08/28/Studies-support-green-lipped-mussel-s-anti-inflammatory-properties#.
9. Mlcek J, Jurikova T, Skrovankova S, Sochor J. Quercetin and Its Anti-Allergic Immune Response. Molecules. 2016;21(5):623. Published 2016 May 12. doi:10.3390/molecules21050623
10. Diesel, Alison. “Cutaneous Hypersensitivity Dermatoses in the Feline Patient: A Review of Allergic Skin Disease in Cats.” Veterinary sciences vol. 4,2 25. 9 May. 2017, doi:10.3390/vetsci4020025
11. Dryden, Michael W. Mite Infestation (Mange, Acariasis, Scabies) of Cats - Cat Owners. Merck Veterinary Manual, Merck Veterinary Manual, Aug. 2018, www.merckvetmanual.com/cat-owners/skin-disorders-of-cats/mite-infestation-mange,-acariasis,-scabies-of-cats.
12. Kennis, Robert A. â€œFeline Alopecia (Proceedings).â€Â DVM 360, 1 May 2011, www.dvm360.com/view/feline-alopecia-proceedings.
13. Wag! Skin Mite Dermatitis in Cats - Symptoms, Causes, Diagnosis, Treatment, Recovery, Management, Cost. WagWalking, 27 Oct. 2016, wagwalking.com/cat/condition/skin-mite-dermatitis.
14. Dwivedi SK, Sharma MC. Therapeutic evaluation of an indigenous drug formulation against scabies in pigs. Indian J Vet Med. 1985;5:97–100.
15. Goldenseal. National Center for Complementary and Integrative Health, U.S. Department of Health and Human Services, Sept. 2016, www.nccih.nih.gov/health/goldenseal.
16. Akram, Muhammad, et al. Therapeutic Potential of Medicinal Plants for the Management of Scabies.Wiley Online Library, John Wiley & Sons, Ltd, 19 Dec. 2019, onlinelibrary.wiley.com/doi/full/10.1111/dth.13186.
17. Moriello, Karen. “Feline dermatophytosis: aspects pertinent to disease management in single and multiple cat situations.” Journal of feline medicine and surgery vol. 16,5 (2014): 419-31. doi:10.1177/1098612X14530215
18. Chávez-Quintal, Pedro et al. “Antifungal Activity in Ethanolic Extracts of Carica papaya L. cv. Maradol Leaves and Seeds.” Indian journal of microbiology vol. 51,1 (2011): 54-60. doi:10.1007/s12088-011-0086-5
19. Surjushe, Amar et al. “Aloe vera: a short review.” Indian journal of dermatology vol. 53,4 (2008): 163-6. doi:10.4103/0019-5154.44785
20. Moghadamtousi, Soheil Zorofchian et al. “A review on antibacterial, antiviral, and antifungal activity of curcumin.” BioMed research international vol. 2014 (2014): 186864. doi:10.1155/2014/186864
21. Hyperthyroidism in Cats. Cornell University College of Veterinary Medicine, 23 July 2017, www.vet.cornell.edu/departments-centers-and-institutes/cornell-feline-health-center/health-information/feline-health-topics/hyperthyroidism-cats.
22. Pierson, Lisa A. Feline Hyperthyroidism. Cat Info, Nov. 2016, catinfo.org/feline-hyperthyroidism/.
23. Wakeling J, Elliott J, Syme H. Evaluation of predictors for the diagnosis of hyperthyroidism in cats. J Vet Intern Med 2011;25(5):1057-1065.)
24. Koestel ZL, Backus RC, Tsuruta K, et al. Bisphenol A (BPA) in the serum of pet dogs following short-term consumption of canned dog food and potential health consequences of exposure to BPA. Sci Total Environ. 2017;579:1804‐1814. doi:10.1016/j.scitotenv.2016.11.162
25. Yildirim, Serap et al. “Dose-dependent protective effect of L-carnitine on oxidative stress in the livers of hyperthyroid rats.” The Eurasian journal of medicine vol. 45,1 (2013): 1-6. doi:10.5152/eajm.2013.01
26. Benvenga, Salvatore et al. “Nutraceutical Supplements in the Thyroid Setting: Health Benefits beyond Basic Nutrition.” Nutrients vol. 11,9 2214. 13 Sep. 2019, doi:10.3390/nu11092214
27. Bugleweed (Lycopus Virginicus).â€Â Restorative Medicine, restorativemedicine.org/library/monographs/bugleweed/.
28. Calsolaro, Valeria et al. “Thyroid Disrupting Chemicals.” International journal of molecular sciences vol. 18,12 2583. 1 Dec. 2017, doi:10.3390/ijms18122583
29. Sarne D. Effects of the Environment, Chemicals and Drugs on Thyroid Function. [Updated 2016 Sep 27]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.
30. Olczak J, Jones BR, Pfeiffer DU, Squires RA, Morris RS, Markwell PJ. Multivariate analysis of risk factors for feline hyperthyroidism in New Zealand. N Z Vet J. 2005;53(1):53‐58. doi:10.1080/00480169.2005.36469
31. Noli, Chiara. Non-Inflammatory Alopecia in Cats - WSAVA 2003 Congress - VIN.Powered By VIN, 2003, www.vin.com/apputil/content/defaultadv1.aspx?pId=8768&catId=18812&id=3850097.
32. Scott DW. Adenite sébacée pyogranulomateuse stérile chez un chat. Point Vét. 21:107, 1989.
33. Al-Waili NS. Therapeutic and prophylactic effects of crude honey on chronic seborrheic dermatitis and dandruff. Eur J Med Res. 2001;6(7):306‐308.
34. Hay IC, Jamieson M, Ormerod AD. Randomized trial of aromatherapy. Successful treatment for alopecia areata. Arch Dermatol. 1998;134(11):1349‐1352. doi:10.1001/archderm.134.11.1349
35. Power HT et al. Novel feline alopecia areata-like dermatosis. Cytotoxic T lymphocytes target the follicular isthmus. In: kwochka KW. et al (eds): Advances in Veterinary Dermatology Vol 3. Butterworth-Heinemann, Boston, 1998:538.
36. Godfrey DR. A case of paraneoplastic alopecia with secondary Malassezia-associated dermatitis. J Small Anim Pract39:394, 1985
37. Hodson S et al. Resolution of paraneoplastic alopecia following surgical removal of a pancreatic carcinoma in a cat. Proceedings ESVD/ECVD, 14: 107, 1997
38. Tasker S. et al. Resolution of paraneoplastic alopecia following surgical removal of pancreatic carcinoma in a cat. J Small Anim Pract 40:16, 1999.
39. Ehrenzweig J. Novel Fiber-rich Supplement Effective for Prevention and Treatment of Acute, Episodic and Chronic Anal Gland Disease in Dogs and Cats. Int J Vet Anim Med. 2018 Jan;1(1):104
40. Lee, Jennifer.Â The Inner CarnivoreÂ . Lulu, 2014.
41. Southlakevet. ANAL GLAND ISSUES IN DOGS.Southlake Animal Hospital P.C., 19 Sept. 2018, merrillvillevets.com/2018/09/19/anal-gland-issues-in-dogs/.
42. Burnett, B. P, Kristol K, Stenstrom, Mary J. Baarsch et al. A flavonoid mixture, dual inhibitor of cyclooxygenase and 5-lipoxygenase enzymes, shows superiority to glucosamine/chondroitin for pain management in moderate osteoarthritic dogs. Intern J Appl Res Vet Med. 2009 Jan; 7(1&2): 1-12.
43. Dr. Pitcairn's Complete Guide to Natural Health for Dogs & Cats By Richard H. Pitcairn
44. Handl, Stephanie, and Julia Fritz. The Water Requirements and Drinking Habits of Cats.Veterinary Focus, Nov. 2018, vetfocus.royalcanin.com/en/doc-10.html.
45. Dierenfeld, Ellen S, Heather L. Alcorn, and Krista L. Jacobsen. Nutrient Composition of Whole Vertebrate Prey (excluding Fish) Fed in Zoos. Beltsville, Md: U.S. Dept. of Agriculture, Agricultural Research Service, National Agricultural Library, Animal Welfare Information Center, 2002. Print.
46. Altarac, Silvio, and Dino PapeÅ¡. â€œUse of dâ€Mannose in Prophylaxis of Recurrent Urinary Tract Infections (UTIs) in Women.â€Â BJU International, John Wiley & Sons, Ltd, 13 Dec. 2013, bjui-journals.onlinelibrary.wiley.com/doi/full/10.1111/bju.12492.
47. Tinelli, et al. â€œOral D-Mannose in Recurrent Urinary Tract Infections in Women: a Pilot Study - D Porru, A Parmigiani, C Tinelli, D Barletta, D Choussos, C Di Franco, V Bobbi, S Bassi, O Miller, B Gardella, RE Nappi, A Spinillo, B Rovereto, 2014.â€Â SAGE Journals, 10 Jan. 2014, journals.sagepub.com/doi/10.1177/2051415813518332.
48. Jacob Inbaneson, S., Ravikumar, S. & Manikandan, N. Antibacterial potential of silver nanoparticles against isolated urinary tract infectious bacterial pathogens. Appl Nanosci 1, 231–236 (2011). https://doi.org/10.1007/s13204-011-0031-2
49. Peter J. Markwell, C. Tony Buffington, Brigitte H. E. Smith, The Effect of Diet on Lower Urinary Tract Diseases in Cats, The Journal of Nutrition, Volume 128, Issue 12, December 1998, Pages 2753S–2757S, https://doi.org/10.1093/jn/128.12.2753S
50. Buffington, C A T. “Idiopathic cystitis in domestic cats--beyond the lower urinary tract.” Journal of veterinary internal medicine vol. 25,4 (2011): 784-96. doi:10.1111/j.1939-1676.2011.0732.x
51. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research [published correction appears in Altern Med Rev. 2009 Sep;14(3):277]. Altern Med Rev. 2009;14(2):141‐153.
52. Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 2004;23(57):9247‐9258. doi:10.1038/sj.onc.1208169
53. Li, Guipu et al. “Anti-inflammatory activity and mechanism of a lipid extract from hard-shelled mussel (Mytilus coruscus) on chronic arthritis in rats.” Marine drugs vol. 12,2 568-88. 27 Jan. 2014, doi:10.3390/md12020568
54. Rainsford KD, Whitehouse MW. Gastroprotective and anti-inflammatory properties of green lipped mussel (Perna canaliculus) preparation. Arzneimittelforschung. 1980;30(12):2128‐2132.
55. Moskowitz RW. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum. 2000;30(2):87‐99. doi:10.1053/sarh.2000.9622
56. Xie, S H. â€œAcupuncture for Osteoarthritis and Pain Management - WSAVA 2015 Congress - VIN.â€Â Powered By VIN, 2015, www.vin.com/apputil/content/defaultadv1.aspx?pId=14365&catId=73691&id=7259351.
57. Zunhui, G. (1995) Effects of acupuncture on immunoglobulins in patients with asthma and rheumatoid arthritis. J. Tradit. Chin. Med. 15:102-105.
58. Schuelert N, McDougall JJ. The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55. Neurosci Lett. 2011;500(1):72‐76. doi:10.1016/j.neulet.2011.06.004
59. Hammell, D C et al. “Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis.” European journal of pain (London, England) vol. 20,6 (2016): 936-48. doi:10.1002/ejp.818
60. Philpott HT, OʼBrien M, McDougall JJ. Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain. 2017;158(12):2442‐2451. doi:10.1097/j.pain.0000000000001052
61. Jantsch J, Schatz V, Friedrich D, et al. Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense. Cell Metab. 2015;21(3):493‐501. doi:10.1016/j.cmet.2015.02.003
62. Billinghurst I. Give your dog a bone: the practical commonsense way to feed dogs for a long healthy life. Alexandria, NSW, Australia: Bridge Printery Ian Billinghurst, 1993.
63. Schultze KR, ed. Natural nutrition for dogs and cats: the ultimate diet. Carlsbad, Calif: Hay House Inc, 1998.
64. Volhard W, Brown KL. The holistic guide for a healthy dog. New York: Howell Book House, 1995
65. Moriello, Karen A. â€œHair Loss (Alopecia) in Cats - Cat Owners.â€Â Merck Veterinary Manual, Merck Veterinary Manual, Aug. 201AD, www.merckvetmanual.com/cat-owners/skin-disorders-of-cats/hair-loss-alopecia-in-cats?query=hair%2Bloss.
66. Willemse T et al. Feline psychogenic alopecia and the role of the opioid system. In: von Tscharner C, Halliwell REW (eds): Advance in Veterinary Dermatology Vol. 1. Balliere Tindall, London, 1990:195.
67. Frank, Diane. Feline Obsessive-Compulsive Disorders - WSAVA 2001. VIN, 2001, www.vin.com/apputil/content/defaultadv1.aspx?id=3843671&pid=8708&print=1.
68. Total Cat Mojo: The Ultimate Guide to Life with Your Cat Book by Bobby Rock, Jackson Galaxy, and Mikel Delgado
69. Armstrong, N.C., and E. Ernst. â€œA Randomized, Double-Blind, Placebo-Controlled Trial of a Bach Flower Remedy.â€Â Complementary Therapies in Nursing and Midwifery, Churchill Livingstone, 25 May 2002, www.sciencedirect.com/science/article/abs/pii/S1353611701905256.
70. Ellis S.L.H., Wells D.L. The influence of olfactory stimulation on the behaviour of cats housed in a rescue shelter. Appl. Anim. Behav. Sci. 2010;123:56–62. doi: 10.1016/j.applanim.2009.12.011.
71. Bol, Sebastiaan et al. “Responsiveness of cats (Felidae) to silver vine (Actinidia polygama), Tatarian honeysuckle (Lonicera tatarica), valerian (Valeriana officinalis) and catnip (Nepeta cataria).” BMC veterinary research vol. 13,1 70. 16 Mar. 2017, doi:10.1186/s12917-017-0987-6
72. Sawyer LS et al. Psychogenic alopecia in cats: 11 cases (19931996). J Am Vet Med Assoc 214:71, 1999.